Coupling Methodology within the Software Platform Alliances

CEA, ANDRA and EDF are jointly developing the software platform ALLIANCES which aim is to produce a tool for the simulation of nuclear waste storage and disposal repository. This type of simulations deals with highly coupled thermo-hydro-mechanical and chemical (T-H-M-C) processes. A key objective of Alliances is to give the capability for coupling algorithms development between existing codes. The aim of this paper is to present coupling methodology use in the context of this software platform.Comment: 7 page

Probleme hyperbolique non lineaire perturbe par un terme de convolution : methodes pseudo-spectrales et capture de choc pour des equations hyperboliques

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

CES coopératif Jules Vallès de la Ricamarie

Denis Alain, Dimier René. CES coopératif Jules Vallès de la Ricamarie. In: Revue française de pédagogie, volume 45, 1978. Didactique des Sciences et Psychologie - Paris, 4-5-6-7 mai 1977. Table Ronde organisée avec le soutien du Centre National de la Recherche Scientifique et de la Maison des Sciences de l'Homme. pp. 200-201

Du contrat d'apprentissage à la prise de décisions

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Mathématiques et Coopération : L'enfant volé de ses connaissances

National audienceCet article sous la forme d'un dialogue tente d'expliciter l'association entre deux termes Mathématiques et Coopération et comment la recherche en didactique pourrait les prendre considération en tant qu'objets. Ce texte est ensuite prolonger par un apport de la théorie des champs conceptuels par Gérard Vergnaud et de la théorie du conflit socio-cognitif présentée par Jean Bru

Du contrat d'apprentissage à la prise de décisions

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Conception, synthesis and evaluation of new Toxoplasma gondii inhibitors designed to target CDPK1

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Multicenter Evaluation of Whole-Blood Epstein-Barr Viral Load Standardization Using the WHO International Standard

International audienceThe first WHO international standard for Epstein-Barr virus (EBV) (WHO EBV standard) for nucleic acid amplification technology (NAT)-based assays was commercialized in January 2012 by the National Institute for Biological Standards and Control. In the study reported here, we compared whole-blood EBV DNA load (EDL) results from 12 French laboratories for seven samples (Quality Controls for Molecular Diagnostics 2013 proficiency panel) in order to determine whether expression in international units reduces interlaboratory variability in whole-blood EDLs. Each testing laboratory used a conversion factor to convert EDL results from copies per milliliter to international units per milliliter. This conversion factor was calculated from the WHO EBV standard according to the protocol described in this study (nine laboratories) or the recommendations of the PCR kit suppliers (three laboratories). The interlaboratory variability in whole-blood EDL results was reduced after standardization of the results using the WHO EBV standard. For the seven samples tested, standard deviations (SD) ranged from 0.41 to 0.55 when the results were expressed in log copies per milliliter, whereas the SD ranged from 0.17 to 0.32 when results were given in log international units per milliliter. Comparing the variance data (F test), we showed that the dispersion of whole-blood EDL results was significantly lower when they were expressed in log international units per milliliter (P < 0.001 for six of seven samples and P < 0.05 for one sample with a low mean EDL of 2.62 log IU/ml). This study showed that the use of the WHO EBV standard could improve the homogeneity of whole-blood EDL results between laboratories as well as the monitoring of patients at high risk of posttransplant lymphoproliferative disorders or other EBV-associated diseases

Conception, synthesis and evaluation of new anti-<em>Toxoplasma gondii</em> agents designed to target CDPK1

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Conception, synthèse et évaluation de nouveaux inhibiteurs de CDPK1 à visée anti-apicomplexes

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